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Illudin M

CAS No. 1146-04-9

Illudin M( —— )

Catalog No. M34856 CAS No. 1146-04-9

Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Illudin M
  • Note
    Research use only, not for human use.
  • Brief Description
    Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds.
  • Description
    Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.
  • In Vitro
    Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.Apoptosis Analysis Cell Line:Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) Concentration:0.01 μM, 1 μM, 10 μM Incubation Time:24 hours, 48 hours,72 hours, 96 hours, 120 hours Result:Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DNA Alkylator/Crosslinker | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1146-04-9
  • Formula Weight
    248.32
  • Molecular Formula
    C15H20O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C2[C@@H](O)C(C)(C)C=C2C(=O)[C@](C)(O)C11CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.?
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